Article Dans Une Revue Peer Community Journal Année : 2023

Chikungunya intra-vector dynamics in Aedes albopictus from Lyon (France) upon exposure to a human viremia-like dose range reveals vector barrier’s permissiveness and supports local epidemic potential

Sébastian Lequime

Résumé

Arbovirus emergence and epidemic potential, as approximated by the vectorial capacity formula, depends on host and vector parameters, including the vector’s intrinsic ability to replicate then transmit the pathogen known as vector competence. Vector competence is a complex, time dependent, quantitative phenotype influenced by biotic and abiotic factors. A combination of experimental and modelling approaches is required to assess arbovirus intra-vector dynamics and estimate epidemic potential. In this study, we measured infection, dissemination, and transmission dynamics of chikungunya virus (CHIKV) in a field-derived Aedes albopictus population (Lyon, France) after oral exposure to a range of virus doses spanning human viraemia. Statistical modelling indicates rapid and efficient CHIKV progression in the vector mainly due to an absence of a dissemination barrier, with 100% of the infected mosquitoes ultimately exhibiting a disseminated infection, regardless of the virus dose. Transmission rate data revealed a time-dependent, but overall weak, transmission barrier, with individuals transmitting as soon as 2 days post-exposure (dpe) and =50% infectious mosquitoes at 6 dpe for the highest dose. Based on these experimental intra-vector dynamics data, epidemiological simulations conducted with an agent-based model showed that even at low mosquito biting rates, CHIKV could trigger outbreaks locally. Together, this reveals the epidemic potential of CHIKV upon transmission by Aedes albopictus in mainland France.

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DOI

Cite 10.5281/zenodo.8033668 Jeu de données Viginier, B., Cappuccio, L., Garnier, C., Martin, E., Maisse, C., Moro, C. V., Minard, G., Fontaine, A., Lequime, S., Ratinier, M., Arnaud, F., & Raquin, V. (2023). Chikungunya intra-vector infection dynamics in a French Aedes albopictus population reveals low vector barrier intensity and supports an explosive epidemic potential [Data set]. Zenodo. https://doi.org/10.5281/ZENODO.8033668

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hal-04440734 , version 1 (06-02-2024)

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Barbara Viginier, Lucie Cappuccio, Céline Garnier, Edwige Martin, Carine Maisse, et al.. Chikungunya intra-vector dynamics in Aedes albopictus from Lyon (France) upon exposure to a human viremia-like dose range reveals vector barrier’s permissiveness and supports local epidemic potential. Peer Community Journal, 2023, 3 (e96), ⟨10.1101/2022.11.06.22281997⟩. ⟨hal-04440734⟩
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