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Article Dans Une Revue Life Sciences Année : 2024

G-quadruplex ligands in cancer therapy: Progress, challenges, and clinical perspectives

Résumé

Guanine-rich sequences can form G-quadruplexes (G4) in living cells, making these structures promising anti- cancer targets. Compounds able to recognize these structures have been investigated as potential anticancer drugs; however, no G4 binder has yet been approved in the clinic. Here, we describe G4 ligands structure-activity relationships, in vivo effects as well as clinical trials. Addressing G4 ligand characteristics, targeting challenges, and structure-activity relationships, this review provides insights into the development of potent and selective G4-targeting molecules for therapeutic applications.
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Dates et versions

hal-04440599 , version 1 (06-02-2024)

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Joana Figueiredo, Jean-Louis Mergny, Carla Cruz. G-quadruplex ligands in cancer therapy: Progress, challenges, and clinical perspectives. Life Sciences, 2024, 340, pp.122481. ⟨10.1016/j.lfs.2024.122481⟩. ⟨hal-04440599⟩
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