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Article Dans Une Revue Respiratory Physiology & Neurobiology Année : 2023

KCNK3 channel is important for the ventilatory response to hypoxia in rats

Résumé

To clarify the contribution of KCNK3/TASK-1 channel chemoreflex in response to hypoxia and hypercapnia, we used a unique Kcnk3-deficient rat. We assessed ventilatory variables using plethysmography in Kcnk3-deficient and wild-type rats at rest in response to hypoxia (10% O2) and hypercapnia (4% CO2). Immunostaining for C-Fos, a marker of neuronal activity, was performed to identify the regions of the respiratory neuronal network involved in the observed response. Under basal conditions, we observed increased minute ventilation in Kcnk3-deficient rats, which was associated with increased c-Fos positive cells in the ventrolateral region of the medulla oblongata. Kcnk3-deficient rats show an increase in ventilatory response to hypoxia without changes in response to hypercapnia. In Kcnk3-deficient rats, linked to an increased hypoxia response, we observed a greater increase in c-Fos-positive cells in the first central relay of peripheral chemoreceptors and Raphe Obscurus. This study reports that KCNK3/TASK-1 deficiency in rats induces an inadequate peripheral chemoreflex, alternating respiratory rhythmogenesis, and hypoxic chemoreflex.
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hal-04432821 , version 1 (01-02-2024)

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  • HAL Id : hal-04432821 , version 1

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Céline-Hivda Yegen, Mélanie Lambert, Antoine Beurnier, David Montani, Marc Humbert, et al.. KCNK3 channel is important for the ventilatory response to hypoxia in rats. Respiratory Physiology & Neurobiology, 2023. ⟨hal-04432821⟩
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