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Communication Dans Un Congrès Année : 2023

Structural Biology on Protein cages and macromolecular assemblies: structure, dynamic and function from an integrative structural biology approach

Diego Gauto

Résumé

Enzymes encapsulation inside shell-forming protein cages represents a powerful strategy for controlling catalytic activity in living organisms due to the reaction pathways can be restricted to specific compartments (e.g. the encapsulins are widespread examples in the prokaryotic realm). Hence, the goals of my current research aims to understand, the structural relation between the encapsulins protein cages and their encapsulated proteins at atomistic level, shed light over the atomistic details of the capsid stability and also find new small molecules (drug-like) that can interfere the multimeric self-assembly equilibria in order to reach a biomedical and biotechnological impact. The main concerns and last progress on my lab in the context of the protein cages will be presented

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Chimie
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Dates et versions

hal-04431185 , version 1 (01-02-2024)

Identifiants

  • HAL Id : hal-04431185 , version 1

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Diego Gauto. Structural Biology on Protein cages and macromolecular assemblies: structure, dynamic and function from an integrative structural biology approach. GdR MéDynA, Oct 2023, VVF de Kerjouanno (56640, Arzon), France, France. ⟨hal-04431185⟩
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