Structural Biology on Protein cages and macromolecular assemblies: structure, dynamic and function from an integrative structural biology approach
Résumé
Enzymes encapsulation inside shell-forming protein cages represents a powerful strategy for
controlling catalytic activity in living organisms due to the reaction pathways can be restricted to
specific compartments (e.g. the encapsulins are widespread examples in the prokaryotic realm).
Hence, the goals of my current research aims to understand, the structural relation between the
encapsulins protein cages and their encapsulated proteins at atomistic level, shed light over the
atomistic details of the capsid stability and also find new small molecules (drug-like) that can interfere
the multimeric self-assembly equilibria in order to reach a biomedical and biotechnological impact.
The main concerns and last progress on my lab in the context of the protein cages will be presented