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Communication Dans Un Congrès Année : 2021

Protein cages nano-compartments: protein structure and dynamics from an integrative structural biology approach

Diego Gauto

Résumé

Enzymes encapsulation represent a powerful strategy for controlling catalytic activity in living organisms due to the reaction pathways can be restricted to specific compartments. In the nature, this is typically overcome by membrane-bound structures or smaller shell-forming as for example the carboxysomes or the encapsulins nanocompartments between many others. Hence, the goals of my research rely to understand the basis underlying the mechanism path for the cage self-assembly using the encapsulins systems as benchmark, shed light over the atomistic details of the capsid stability and also find new drug-like compounds that can promote their structural collapsing. On the other hand, I am interested in develop methods for capsid functionalization in order to target cancer cells. My research will be performed under an integrative structural biology framework combining solid and liquid state NMR, biochemistry and computational simulations

Domaines

Chimie
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Dates et versions

hal-04431170 , version 1 (01-02-2024)

Identifiants

  • HAL Id : hal-04431170 , version 1

Citer

Diego Gauto. Protein cages nano-compartments: protein structure and dynamics from an integrative structural biology approach. GdR MéDynA 2 ème Réunion, Sep 2021, Île d'Oléron, France. ⟨hal-04431170⟩
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