Protein cages nano-compartments: protein structure and dynamics from an integrative structural biology approach
Résumé
Enzymes encapsulation represent a powerful strategy for controlling catalytic activity in living
organisms due to the reaction pathways can be restricted to specific compartments. In the nature,
this is typically overcome by membrane-bound structures or smaller shell-forming as for example the
carboxysomes or the encapsulins nanocompartments between many others. Hence, the goals of my
research rely to understand the basis underlying the mechanism path for the cage self-assembly using
the encapsulins systems as benchmark, shed light over the atomistic details of the capsid stability and
also find new drug-like compounds that can promote their structural collapsing. On the other hand, I
am interested in develop methods for capsid functionalization in order to target cancer cells. My
research will be performed under an integrative structural biology framework combining solid and
liquid state NMR, biochemistry and computational simulations