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Article Dans Une Revue Acta Psychiatrica Scandinavica Année : 2024

Incidence and predictors of metabolic syndrome onset in individuals with bipolar disorders: A longitudinal study from the FACE‐BD cohort

O. Godin (1, 2) , E. Olié (1, 3, 4) , G. Fond (1, 5) , B. Aouizerate (1, 6, 7) , V. Aubin (8, 1) , F. Bellivier (9, 1, 10, 11) , R. Belzeaux (3, 1) , P. Courtet (3, 1, 4) , C. Dubertret (1, 12) , E. Haffen (1, 13, 14) , A. Lefrere (1, 15, 16) , P. Llorca (1, 17, 18) , M. Polosan (19, 20, 1) , P. Roux (1, 21, 22) , L. Samalin (1, 17, 18) , R. Schwan (1, 23, 24) , M. Leboyer (1, 2, 25) , B. Etain (9, 11, 1, 10)

Résumé

Introduction: Metabolic syndrome (MetS) is a cluster of components including abdominal obesity, hyperglycemia, hypertension, and dyslipidemia. MetS is highly prevalent in individuals with bipolar disorders (BD) with an estimated global rate of 32.6%. Longitudinal data on incident MetS in BD are scarce and based on small sample size. The objectives of this study were to estimate the incidence of MetS in a large longitudinal cohort of 1521 individuals with BD and to identify clinical and biological predictors of incident MetS. Methods: Participants were recruited from the FondaMental Advanced Center of Expertise for Bipolar Disorder (FACE-BD) cohort and followed-up for 3 years. MetS was defined according to the International Diabetes Federation criteria. Individuals without MetS at baseline but with MetS during follow-up were considered as having incident MetS. A logistic regression model was performed to estimate the adjusted odds ratio and its corresponding 95% confidence interval (CI) for an association between each factor and incident MetS during follow-up. We applied inverse probability-of-censoring weighting method to minimize selection bias due to loss during follow-up. Results: Among individuals without MetS at baseline (n = 1521), 19.3% developed MetS during follow-up. Multivariable analyses showed that incident MetS during follow-up was significantly associated with male sex (OR = 2.2, 95% CI = 1.7-3.0, p < 0.0001), older age (OR = 2.14, 95% CI = 1.40-3.25, p = 0.0004), presence of a mood recurrence during follow-up (OR = 1.91, 95% CI = 1.22-3.00, p = 0.0049), prolonged exposure to second-generation antipsychotics (OR = 1.56, 95% CI = 0.99, 2.45, p = 0.0534), smoking status at baseline (OR = 1.30, 95% CI = 1.00-1.68), lifetime alcohol use disorders (OR = 1.33, 95% CI = 0.98-1.79), and baseline sleep disturbances (OR = 1.04, 95% CI = 1.00-1.08), independently of the associations observed for baseline MetS components. Conclusion: We observed a high incidence of MetS during a 3 years follow-up (19.3%) in individuals with BD. Identification of predictive factors should help the development of early interventions to prevent or treat early MetS.
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Dates et versions

hal-04430801 , version 1 (01-02-2024)

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Citer

O. Godin, E. Olié, G. Fond, B. Aouizerate, V. Aubin, et al.. Incidence and predictors of metabolic syndrome onset in individuals with bipolar disorders: A longitudinal study from the FACE‐BD cohort. Acta Psychiatrica Scandinavica, 2024, 149 (3), pp.207-218. ⟨10.1111/acps.13655⟩. ⟨hal-04430801⟩
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