Visible-Light-Driven Decarboxylative Borylation: Rapid Access to α- and β-Amino-boronamides
Résumé
In this study, we described a two steps process involving an efficient visible light-induced borylation of α-and β-amino redox-active esters with bis(catecholato)diboron followed by transamination with 1,8-diaminonapthalene (DANH2). A series of boronamides were obtained in moderate to excellent yields in this one-pot procedure. This protocol could be applied to a broad range of conventionally challenging substrates, including α-oxoacid and tertiary carboxylic acid derivatives. The photochemical process proved to be very efficient even when conducted under flow conditions, with shorter reaction durations and scalable synthesis of DAN boronates.
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