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Article Dans Une Revue Journal of Thermal Analysis and Calorimetry Année : 2023

Pharmaceutical phase diagram: aspirin-caffeine-paracetamol

Résumé

In recent years, eutectic mixtures have been the subject of numerous scientifc studies aimed at improving the therapeutic efcacy of drugs. In this work, we focused our attention on the eutectic mixture of aspirin, cafeine and paracetamol by determining its coordinates, i.e., its composition and temperature. To do this, it is necessary to study the interactions between these three components by establishing their phase diagram and taking into account their polymorphic behavior. All the data were obtained by powder X-ray difraction and diferential scanning calorimetry. This review provides the composition of the eutectic mixture aspirin, cafeine and paracetamol determined from the minimum tie-lines of the eutectic triangle as well as its temperature. A description of the ternary surface of the liquid throughout the composition range is proposed. An additional valley was observed in the ternary system due to cafeine polymorphism

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Chimie
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Dates et versions

hal-04425625 , version 1 (30-01-2024)

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Emma Dichi, Mehrez Sghaier, Nicolas Guiblin. Pharmaceutical phase diagram: aspirin-caffeine-paracetamol. Journal of Thermal Analysis and Calorimetry, 2023, 148 (13), pp.6107-6118. ⟨10.1007/s10973-023-12081-9⟩. ⟨hal-04425625⟩
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