Article Dans Une Revue Human Brain Mapping Année : 2017

Structural and functional brain network correlates of depressive symptoms in premanifest Huntington's disease

Peter Mccolgan
  • Fonction : Auteur
Adeel Razi
  • Fonction : Auteur
Sarah Gregory
  • Fonction : Auteur
Kiran K Seunarine
  • Fonction : Auteur
Raymund A.C. Roos
  • Fonction : Auteur
Blair R Leavitt
  • Fonction : Auteur
Rachael I Scahill
  • Fonction : Auteur
Chris A Clark
  • Fonction : Auteur
Doug R Langbehn
  • Fonction : Auteur
Geraint Rees
  • Fonction : Auteur
Sarah J Tabrizi
  • Fonction : Auteur
  • PersonId : 1343261

Résumé

Depression is common in premanifest Huntington's disease (preHD) and results in significant morbidity. We sought to examine how variations in structural and functional brain networks relate to depressive symptoms in premanifest HD and healthy controls. Brain networks were constructed using diffusion tractography (70 preHD and 81 controls) and resting state fMRI (92 preHD and 94 controls) data. A sub‐network associated with depression was identified in a data‐driven fashion and network‐based statistics was used to investigate which specific connections correlated with depression scores. A replication analysis was then performed using data from a separate study. Correlations between depressive symptoms with increased functional connectivity and decreased structural connectivity were seen for connections in the default mode network (DMN) and basal ganglia in preHD. This study reveals specific connections in the DMN and basal ganglia that are associated with depressive symptoms in preHD.

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Dates et versions

hal-04423324 , version 1 (29-01-2024)

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Peter Mccolgan, Adeel Razi, Sarah Gregory, Kiran K Seunarine, Alexandra Dürr, et al.. Structural and functional brain network correlates of depressive symptoms in premanifest Huntington's disease. Human Brain Mapping, 2017, 38 (6), pp.2819-2829. ⟨10.1002/hbm.23527⟩. ⟨hal-04423324⟩
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