Design for Re-X (reuse, remanufacturing, recycling) in a multi-generational product family setup is a challenging task that requires new and more advanced, quantitative, and user-friendly tools to ensure environmental savings and economic profitability for product makers. Through this REMADE-funded project, state-of-the-art Re-X, reliability, and lifecycle-based models are combined within a new design tool in order to generate and compare designs for Re-X alternatives. This newly developed Calculator aims to assess the potential of reliability-informed analysis of long-term benefits/costs of Re-X in product family design to enable substantial reductions in embodied energy and carbon emissions. To do so, three integrated modules are working together: (i) the LCA/LCC module; (ii) the reliability module; and (iii), the Re-X policy optimization module. Notably, the lifecycle-based module allows testing and comparing the impact of different material alternatives, part designs, and sub-assemblies. In addition, the Re-X and reliability analysis modules enable to compare and optimize different designs based on, e.g., material composition, the percentage of remanufactured components, the energy consumption, or the remaining useful life of critical components. In particular, for the reliability module, the inputs are the following: the shape/scale from reliability info or estimated using warranty claims, the warranty length (provided from the product or part information), the total number of new and used parts, and the weight (initial weight of product/subassembly being evaluated). The outputs enable the user to estimate the additional units for warranty claims, the reuse rate, and the adjusted weight. The Re-X policy optimization module includes: the bi-objective function (as of now, minimize cost and energy consumption), the Pareto front exploration, the impact of component reliability, the impact of warranty length, the impact of return rate, and the impact of remanufacturing cost. This new Re-X Calculator is being tested, fine-tuned, and validated based on two complementary product family categories (utility tractor product family design problem and mobile phone design and recovery problem) provided by the industrial partners, John Deere and Global Electronics Council.