This collection of essays examines the relationship between illustration and adaptation from an intermedial and transcultural perspective. It aims to foster an interdisciplinary dialogue between two fields that co-exist without necessarily acknowledging advances in each other’s domains. It provides an argument for defining illustration as a form of adaptation as well as an intermedial practice that redefines what we mean by adaptation. The volume embraces both a specific and an extended defnition of illustration that accounts for its inclusion among the web of adaptive practices that developed with the rise of new media and intermediality. The contributors explore how crossovers may contribute to reappraise the objects they scrutinize and their theoretical remits. The essays provide original perspectives by prominent authors, young scholars and practitioners. They rely on a transmedial and interdisciplinary corpus that allows us to explore the boundaries between illustration and other media such as texts, graphic novels, comics, theatre, film and mobile applications. Arguably adaptation, like intermediality, is an umbrella term that covers a variety of practices and products, and both of them have been shaped by intense debates over their boundaries and internal defnitions. Illustration belongs to each of these areas, and what this volume proposes is an insight into how illustration not only relates to adaptation and intermediality, but how each feld is redefned, enriched and also challenged by such interactions.