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Poster De Conférence Année : 2019

Multi-composite coatings of silicon doped hydroxyapatite on stainless steel 316L for orthopedic applications

Résumé

Implantations of orthopedic prostheses due to diseases/injuries are increasingly common operations correlated to population ageing. Hence there is a real need of new orthopedic implants, time resistant, biocompatible and affordable for most of people. Our work focuses on the development of multilayers onto 316L stainless steel supports for orthopedic surgery. Multilayers are composed of a polymer coating, followed by hydroxyapatite (HAP) deposition. HAP is the main component of bone and it is widely used to improve biocompatibility and biointegration of orthopedic implants. First electropolymerisation of pyrrole is performed onto steel supports to obtain a primary layer of polypyrrole (PPy) by cyclic voltametry. This PPy coating allows passivation of the surface of the steel support and maintain it electrical conductivity. Then a second eletrodeposition of hydroxyapatite doped with different concentration of silicon (Si-HAP) ranging from 0 to 2mM was done. In this study, our multi-composite supports were characterized and effects of silicon addition in structure of HAP (Si-HAP) were investigated. The structure of our different Si-HAP coatings on PPy was characterized by physico-chemical methods of material analysis. The crystallite phase, chemical composition, and crystallite size of hydroxyapatite and silicon substituted HAP were characterized by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). Surfaces of our different multi-composite supports were analyzed and compared either by scanning electron microscopy and profilometry. Behavior of osteoblastic cells (STRO-1A+) cultured on Si-HAP supports was also studied. Silicon doping influenced organization, roughness and thickness of different Si-HAP coatings. Culture of human osteoblastic cells (STRO-1A+) were also carried out onto ours supports to test their biocompatibility and cell behavior induced. The optimal formulation is 0.5 mM Si-HAP coating demonstrating the best physical properties of the supports (roughness, thickness) and the best biocompatibility.
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Dates et versions

hal-04420611 , version 1 (26-01-2024)

Identifiants

  • HAL Id : hal-04420611 , version 1

Citer

Séverine Alfonsi, Soria Hamdaoui, Ambroise Lambert, Haffit Khiredine, Mathilde Hindié, et al.. Multi-composite coatings of silicon doped hydroxyapatite on stainless steel 316L for orthopedic applications. 6th International Symposium Interface Biology of Implants, May 2019, Rostock, Germany. ⟨hal-04420611⟩
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