While carers’ vulnerability has often been neglected in the literature, the recent COVID-19 pandemic brought this issue to the fore. This article explores why it has been so often ignored and how could it be dealt with differently. It does so in the form of a philosophical and conceptual investigation illustrated by various examples and situations, related primarily, but not exclusively, to the COVID period. Criticising a property-based view, and based on examples of carers’ vulnerability during the pandemic, our investigation suggests that carers’ vulnerability is relationally constructed and played out on multiple interwoven dimensions that may contradict each other. Our examples also suggest that the relational construction of vulnerabilities is socially and organisationally mediated, calling for the development of social and organisational forms of mediation that may help carers deal with their vulnerabilities. Second, and rather counterintuitively with regard to the COVID-period, we question the negative valence usually associated with vulnerability and analyse how this affects ways of dealing with carers’ vulnerabilities and the co-creation of care. Finally, following Gilson (2014), we propose an ambivalent, relational conception of vulnerability, considered as ‘openness to affectation by’ and offer some theoretical and practical implications. Theoretically, this conception also allows us to consider such openness as an ability that may nurture carers’ ‘response-ability’. It also allows us to develop specific relational ethics for and in care relationships. Practically, this reconceptualisation may help carers better embrace and process their vulnerabilities, including responses to negative affectations following exposure to carees. It may also facilitate their ‘reception’ of carees, and help cocreate and adapt responses to carees’ calls, thus avoiding paternalistic responses.