This research aims to analyze the resilience of humanitarian supply chains, with a focus on the role of information systems, through a case study of Médecins Sans Frontières Logistique during the COVID-19 pandemic. The empirical research methodology is based on a qualitative study, which includes semistructured interviews with key actors and operators from the Médecins Sans Frontières Logistique during the COVID-19 crisis in 2020 and 2021. The paper highlights the crucial and inherent role of information systems on each of the four dimensions of humanitarian supply chain resilience: reorganization capacity, collaboration, flexibility, and humanitarian culture. Drawing on recent theoretical works on supply chain resilience as well as empirical results, the paper underscores the importance of information systems and proposes a conceptual model of the relationship between humanitarian supply chain resilience and the role of information systems. The value of this research is linked to its empirical and qualitative study of a Non- Governmental Organization logistics operation during an international crisis, which contributes not only to the literature on resilience, but also provides guidance for managers to target their actions responsively and proactively to enhance resilience over time.