Long-term atorvastatin treatment decreases heart maximal oxygen consumption and its vulnerability to in vitro oxidative stress in Watanabe heritable hyperlipidemic rabbit - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Canadian Journal of Physiology and Pharmacology Année : 2018

Long-term atorvastatin treatment decreases heart maximal oxygen consumption and its vulnerability to in vitro oxidative stress in Watanabe heritable hyperlipidemic rabbit

Résumé

Statins are currently used in prevention of cardiovascular diseases in high risk populations, and could be considered in primary prevention. However, few studies are available on the long-term effects of low-doses of statins, especially on mitochondrial function and ROS (Reactive Oxygen Species) metabolism at cardiac level. This study aimed to determine potential effects of a long-term atorvastatin treatment, at low-dose concentration, on the myocardium mitochondrial respiration. 34 Watanabe rabbits were treated or not with atorvastatin (2.5 mg.Kg-1.Day-1) from the age of 3 to 12 months. Every three months, proton leak, basal (V0) and maximal (Vmax) mitochondrial respiration on cardiac permeabilized fibers were measured. Additionally, the vulnerability to ROS, cardiac enzymatic antioxidant defenses and oxidative damage (lipoperoxidation) were analyzed. Proton leak increased over the duration of the experiment (up to 60% from Vmax at 12 month). Moreover, the statin treatment induced a decrease of Vmax and a decrease of ROS susceptibility of cardiac mitochondria. However, the lipoperoxidation and the antioxidant defenses were not dependent neither on the presence of statin treatment, neither on its duration. This is the first time study showing a protective effect of long-term statins treatment against the ROS susceptibility in the cardiac muscle.
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Dates et versions

hal-04412423 , version 1 (23-01-2024)

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Florine Tissier, Firas Farhat, Clothilde Philouze, Jean-Claude Desfontis, Romain Didier, et al.. Long-term atorvastatin treatment decreases heart maximal oxygen consumption and its vulnerability to in vitro oxidative stress in Watanabe heritable hyperlipidemic rabbit. Canadian Journal of Physiology and Pharmacology, 2018, 96 (11), pp.1112-1118. ⟨10.1139/cjpp-2018-0085⟩. ⟨hal-04412423⟩
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