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Communication Dans Un Congrès Année : 2022

Exotic and xenobiotic deviations from the set of canonical nucleotides

Résumé

The main objective of our team is to design, construct and evolve genetically modified microorganisms that pose no threat to health and the environment (”safe GMOs”). These or- ganisms will use an artificial genetic system based on xenobiotic nucleic acids (XNA) to transmit genetic information. We are also studying the diversification of nucleic acids in the natural liv- ing world, focusing on the genomes of bacteriophages which have a wide chemical diversity of non-canonical nucleic bases. Some viruses infecting hosts such as proteobacteria, cyanobacteria and actinobacteria have a DNA genome in which adenine is completely replaced by aminoade- nine (Z). The elucidation of the biosynthetic pathway of this non-canonical nucleotide and the discovery of bacteriophage polymerases dedicated to the incorporation of this nucleotide into DNA pave the way for the propagation of chemically modified genomes in bacteria (Pezo et al, Science 2021).
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Dates et versions

hal-04409993 , version 1 (22-01-2024)

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  • HAL Id : hal-04409993 , version 1

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Valérie Pezo. Exotic and xenobiotic deviations from the set of canonical nucleotides. Journée Bio-ingénierie et Biologie de Synthèse GS LSH, Nov 2022, Gif sur yvette, France. ⟨hal-04409993⟩
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