Perinatal programming of intestinal homeostasis following exposure to high fat diet in male rats offspring.
Résumé
1. Perinatal HFD : cause of ↗ the occurrence of obesity, associated with metabolic disorders and disturbances of digestive function in male offsprings ? 2. Prebiotic: limitation of observed disorders induced by the HFD ? 4 MONTHS (16 WEEKS) 3 WEEKS 3 WEEKS 9 WEEKS EXPERIMENTAL CONDITIONS MOTHERS (N=16) 10g/L in drinking water Kruskal Wallis with Dunn's post test or ANOVA with Bonferroni's post test ; GraphPad Prism version 5.00-* p<0,05; ** p<0,01; *** p<0,001 Perinatal period is characterized by developmental phases with high sensitivity to the environmental factors. Among the risk factors, malnutrition or maternal obesity are now recognized to program children's metabolism and promote the occurrence of obesity or type 2 diabetes during postnatal life. This work was dedicated to the peri-gestational exposure of dams to an obesogenic diet (high fat diet, HFD) and the exploration of the prebiotic supplementation benefits
Domaines
Sciences du Vivant [q-bio]| Origine | Fichiers produits par l'(les) auteur(s) |
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