Diagnostic yield of viral multiplex PCR during acute exacerbation of COPD admitted to the intensive care unit: a pilot study - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Scientific Reports Année : 2024

Diagnostic yield of viral multiplex PCR during acute exacerbation of COPD admitted to the intensive care unit: a pilot study

Costa Salachas
  • Fonction : Auteur
Gaëtan Beduneau
Julien Lopinto
  • Fonction : Auteur
Corinne Amiel
  • Fonction : Auteur
Antoine Cuvelier
  • Fonction : Auteur
Marie Gueudin
  • Fonction : Auteur

Résumé

Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is one of the leading causes of admission to the intensive care unit, often triggered by a respiratory tract infection of bacterial or viral aetiology. Managing antibiotic therapy in this context remains a challenge. Respiratory panel molecular tests allow identifying viral aetiologies of AECOPD. We hypothesized that the systematic use of a respiratory multiplex PCR (mPCR) would help antibiotics saving in severe AECOPD. Our objectives were to describe the spectrum of infectious aetiologies of severe AECOPD, using a diagnostic approach combining conventional diagnostic tests and mPCR, and to measure antibiotics exposure. The study was bicentric, prospective, observational, and included 105 critically ill patients with a severe AECOPD of presumed infectious aetiology, in whom a respiratory mPCR with a viral panel was performed in addition to conventional microbiological tests. Altogether, the microbiological documentation rate was 50%, including bacteria alone (19%), respiratory viruses alone (16%), and mixed viruses and bacterial species (16%). The duration of antibiotic therapy was shorter in patients without documented bacterial infection (5.6 vs. 9 days; P = 0.0006). This pilot study suggests that molecular tests may help for the proper use of anti-infective treatments in critically ill patients with severe AECOPD.
Fichier principal
Vignette du fichier
Fartoukh_Scientif Reports.pdf (925.57 Ko) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04405470 , version 1 (19-01-2024)

Identifiants

Citer

Costa Salachas, Cherifa Gounane, Gaëtan Beduneau, Julien Lopinto, Matthieu Turpin, et al.. Diagnostic yield of viral multiplex PCR during acute exacerbation of COPD admitted to the intensive care unit: a pilot study. Scientific Reports, 2024, 14, ⟨10.1038/s41598-024-51465-1⟩. ⟨hal-04405470⟩
12 Consultations
5 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More