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Pré-Publication, Document De Travail Année : 2023

The exploration-exploitation paradigm for networked biological systems

Résumé

The stochastic exploration of the configuration space and the exploitation of functional states underlie many biological processes. The evolutionary dynamics stands out as a remarkable example. Here, we introduce a novel formalism that mimics evolution and encodes a general exploration-exploitation dynamics for biological networks. We apply it to the brain wiring problem, focusing on the maturation of that of the nematode C. elegans. We demonstrate that a parsimonious maxent description of the adult brain combined with our framework is able to track down the entire developmental trajectory.
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Dates et versions

hal-04404220 , version 1 (18-01-2024)

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Vito Dichio, Fabrizio de Vico Fallani. The exploration-exploitation paradigm for networked biological systems. 2024. ⟨hal-04404220⟩
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