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Chapitre D'ouvrage Année : 2010

Experimental Models of Itch

Ulysse Pereira

Résumé

Pruritus can be defined as an unpleasant cutaneous sensation that leads to the need to scratch. This “umbrella definition” was proposed more than 360 years ago by the German physician Samuel Hafenreffer and does not describe the complexity of this phenomenon. Activation and control of pruritus may occur at different levels of the skin-brain connection1 like pruritoceptive itch, neurogenic itch, neuropathic itch and psychogenic itch. Because they are different types of pruritus, it is impossible to develop a “universal model of pruritus” and so, different categories of models, according to the purpose of the study, are available. It is obvious that no model is perfect. Each model exhibits advantages for a particular kind of study, and is also restricted by limitations that impede its use in other studies.
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Dates et versions

hal-04404209 , version 1 (18-01-2024)

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Ulysse Pereira, Laurent Misery. Experimental Models of Itch. Misery, L., Ständer, S. Pruritus, Springer London, pp.51-59, 2010, ⟨10.1007/978-1-84882-322-8_9⟩. ⟨hal-04404209⟩
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