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Article Dans Une Revue Journal of Experimental Medicine Année : 2017

Development and plasticity of meningeal lymphatic vessels

Salli Antila
Sinem Karaman
Harri Nurmi
  • Fonction : Auteur
Mikko Airavaara
Merja H Voutilainen
  • Fonction : Auteur
Thomas Mathivet
Dmitri Chilov
  • Fonction : Auteur
Zhilin Li
Tapani Koppinen
Jun-Hee Park
  • Fonction : Auteur
Shentong Fang
  • Fonction : Auteur
Aleksanteri Aspelund
Mart Saarma
  • Fonction : Auteur
Anne Eichmann
  • Fonction : Auteur
Kari Alitalo

Résumé

The recent discovery of meningeal lymphatic vessels (LVs) has raised interest in their possible involvement in neuropathological processes, yet little is known about their development or maintenance. We show here that meningeal LVs develop postnatally, appearing first around the foramina in the basal parts of the skull and spinal canal, sprouting along the blood vessels and cranial and spinal nerves to various parts of the meninges surrounding the central nervous system (CNS). VEGF-C, expressed mainly in vascular smooth muscle cells, and VEGFR3 in lymphatic endothelial cells were essential for their development, whereas VEGF-D deletion had no effect. Surprisingly, in adult mice, the LVs showed regression after VEGF-C or VEGFR3 deletion, administration of the tyrosine kinase inhibitor sunitinib, or expression of VEGF-C/D trap, which also compromised the lymphatic drainage function. Conversely, an excess of VEGF-C induced meningeal lymphangiogenesis. The plasticity and regenerative potential of meningeal LVs should allow manipulation of cerebrospinal fluid drainage and neuropathological processes in the CNS.
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Dates et versions

hal-04403072 , version 1 (18-01-2024)

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Salli Antila, Sinem Karaman, Harri Nurmi, Mikko Airavaara, Merja H Voutilainen, et al.. Development and plasticity of meningeal lymphatic vessels. Journal of Experimental Medicine, 2017, 214 (12), pp.3645-3667. ⟨10.1084/jem.20170391⟩. ⟨hal-04403072⟩
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