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Poster Communications Year : 2022

Stereospecific recognition of amino acids in quaternary coppered complexes via enantioselective reduction

Abstract

A detailed study of the enantioselective reduction of homochiral or heterochiral quaternary coppered complexes (QCCs) [Cu II D/ L Phe, D PhG, D Pro-H)] with Phe as a model compound was performed using collision-induced dissociation while varying collision energy and activation time. The resulting energy-resolved mass spectrometry data were represented via the survival yield method. Additional in silico simulations were carried out within the frame of RRKM theory using MassKinetics Scientific Demo software for further kinetic insights. Enantioselective reduction in [Cu II,(Phe,PhG,Pro-H)]+ complex would be a consequence of the lesser stability of heterochiral complexes, which would favour direct cleavage and the formation of the product ion [Cu II,(Phe,Pro-H)]+ (m/z 342), rather than the result of an increase in the formation of the reduced product ion [Cu I,(Phe, Pro)]+ m/z 343 in homochiral QCCs.
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Dates and versions

hal-04402557 , version 1 (18-01-2024)

Identifiers

  • HAL Id : hal-04402557 , version 1

Cite

Clément Chalet, Ekaterina Darii, Denis Lesage, Estelle Rathahao-Paris, Yves Gimbert, et al.. Stereospecific recognition of amino acids in quaternary coppered complexes via enantioselective reduction. IMSC 2022 - 2022 International Mass Spectrometry Conference, Aug 2022, Maastricht, Netherlands. , IMSC-2022-POSTER-ABSTRACTS. ⟨hal-04402557⟩
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