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Article Dans Une Revue Acta Physiologica Année : 2024

Adult rats sired by obese fathers present learning deficits associated with epigenetic and neurochemical alterations linked to impaired brain glutamatergic signaling

Résumé

Aim: Offspring of obese mothers are at high risk of developing metabolic syndrome and cognitive disabilities. Impaired metabolism has also been reported in the offspring of obese fathers. However, whether brain function can also be affected by paternal obesity has barely been examined. This study aimed to characterize the learning deficits resulting from paternal obesity versus those induced by maternal obesity and to identify the underlying mechanisms.
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hal-04402176 , version 1 (18-01-2024)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Carla Elena Mezo‐gonzález, Juan Antonio García‐santillán, Bertrand Kaeffer, Mathilde Gourdel, Mikaël Croyal, et al.. Adult rats sired by obese fathers present learning deficits associated with epigenetic and neurochemical alterations linked to impaired brain glutamatergic signaling. Acta Physiologica, 2024, ⟨10.1111/apha.14090⟩. ⟨hal-04402176⟩
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