In vivo exposure of the bladder using a non-invasive high intensity focused ultrasound toroidal transducer - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Ultrasonics Année : 2024

In vivo exposure of the bladder using a non-invasive high intensity focused ultrasound toroidal transducer

Résumé

A toroidal high-intensity focused ultrasound (HIFU) transducer was used to expose normal bladder wall tissues non-invasively in vivo in a porcine model in order to investigate the potential to treat bladder tumors. The transducer was divided into 32 concentric rings with equal surface areas, operating at 2.5 MHz. Eight animals were split into two groups of 4. In the first group, post-mortem evaluation was performed immediately after ultrasound exposure. In the second group, animals survived for up to seven days before post-mortem evaluation. The ultrasound imaging guided HIFU device was hand-held during the procedure using optical tracking to ensure correct targeting. One thermal lesion in each animal was created using a 40 s exposure at 80 acoustic Watts (free-field) in the trigone region of the bladder wall. The average (±Standard Deviation) abdominal wall and bladder wall thicknesses were 10.3 ± 1.4 mm and 1.1 ± 0.4 mm respectively. The longest and shortest axes of the HIFU ablations were 7.7 ± 2.9 mm and 6.0 ± 1.8 mm, respectively, resulting in an ablation of the whole thickness of the bladder wall in most cases. Ablation were performed at an average depth (distance from the skin surface to the centre of the HIFU lesion) of 42.5 ± 3.8 mm and extended throughout the thickness of the bladder. There were two cases of injury to tissues immediately adjacent to the bladder wall but without signs of perforation, as confirmed by histological analysis. Non-invasive HIFU ablation using a hand-held toroidal transducer was successfully performed to destroy regions of the bladder wall in vivo.
Fichier principal
Vignette du fichier
2024-01-19-HIFU_Bladder_HAL.pdf (548.46 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04400977 , version 1 (19-01-2024)

Identifiants

Citer

Victor Delattre, Sophie Cambronero, Yao Chen, Gail Ter Haar, Ian Rivens, et al.. In vivo exposure of the bladder using a non-invasive high intensity focused ultrasound toroidal transducer. Ultrasonics, 2024, 138, pp.107239. ⟨10.1016/j.ultras.2024.107239⟩. ⟨hal-04400977⟩

Collections

UNIV-LYON1 UDL
8 Consultations
3 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More