A comprehensive evolutionary scenario for the origin and neofunctionalization of the Drosophila speciation gene Odysseus ( OdsH ) - Archive ouverte HAL Access content directly
Journal Articles G3 Year : 2023

A comprehensive evolutionary scenario for the origin and neofunctionalization of the Drosophila speciation gene Odysseus ( OdsH )

William Vilas Boas Nunes
  • Function : Author
Daniel Siqueira de Oliveira
Guilherme de Rezende Dias
  • Function : Author
Antonio Bernardo Carvalho
Ícaro Putinhon Caruso
  • Function : Author
Joice Matos Biselli
  • Function : Author
Nathalie Guegen
  • Function : Author
Abdou Akkouche
  • Function : Author
Nelly Burlet
  • Function : Author
Claudia Carareto

Abstract

Abstract Odysseus (OdsH) was the first speciation gene described in Drosophila related to hybrid sterility in offspring of mating between D. mauritiana and D. simulans. Its origin is attributed to the duplication of the gene unc-4 in the subgenus Sophophora. By using a much larger sample of Drosophilidae species, we showed that contrary to what has been previously proposed, OdsH origin occurred 62 million years ago. Evolutionary rates, expression and transcription factor binding sites of OdsH evidence that it may have rapidly experienced neofunctionalization in male sexual functions. Furthermore, the analysis of the OdsH peptide allowed the identification of mutations of D. mauritiana that could result in incompatibility in hybrids. In order to find if OdsH could be related to hybrid sterility, beyond Sophophora, we explored the expression of OdsH in D. arizonae and D. mojavensis, a pair of sister species with incomplete reproductive isolation. Our data indicated that OdsH expression is not atypical in their male-sterile hybrids. In conclusion, we have proposed that the origin of OdsH occurred earlier than previously proposed, followed by neofunctionalization. Our results also suggested that its role as a speciation gene might be restricted to D. mauritiana and D. simulans.

Dates and versions

hal-04400854 , version 1 (17-01-2024)

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William Vilas Boas Nunes, Daniel Siqueira de Oliveira, Guilherme de Rezende Dias, Antonio Bernardo Carvalho, Ícaro Putinhon Caruso, et al.. A comprehensive evolutionary scenario for the origin and neofunctionalization of the Drosophila speciation gene Odysseus ( OdsH ). G3, 2023, ⟨10.1093/g3journal/jkad299⟩. ⟨hal-04400854⟩
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