Article Dans Une Revue Nutrition and Metabolism Année : 2016

Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia

Résumé

Background: The human SLC30A8 gene encodes the secretory granule-localised zinc transporter ZnT8 whose expression is chiefly restricted to the endocrine pancreas. Single nucleotide polymorphisms (SNPs) in the human SLC30A8 gene have been associated, through genome-wide studies, with altered type 2 diabetes risk. In addition to a role in the control of insulin release, recent studies involving targeted gene ablation from the pancreatic α cell (Solomou et al., J Biol Chem 290(35):21432-42) have also implicated ZnT8 in the control of glucagon release. Up to now, however, the possibility that increased levels of the transporter in these cells may impact glucagon secretion has not been explored.

Fichier principal
Vignette du fichier
2016 Over-expression of Slc30a8 ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia.pdf (1.95 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
Licence

Dates et versions

hal-04396589 , version 1 (16-01-2024)

Licence

Identifiants

Citer

Antonia Solomou, Erwann Philippe, Pauline Chabosseau, Stephanie Migrenne-Li, Julien Gaitan, et al.. Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia. Nutrition and Metabolism, 2016, 13 (1), pp.46. ⟨10.1186/s12986-016-0104-z⟩. ⟨hal-04396589⟩
46 Consultations
58 Téléchargements

Altmetric

Partager

  • More