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Article Dans Une Revue European Journal of Organic Chemistry Année : 2022

The Selective Nickel‐Catalyzed N ‐Allylation of C3‐Unprotected Indoles under Mild and Clean Conditions

Résumé

Abstract A simple salt free and selective N ‐allylation of indoles with allylic alcohols has been developed. The protocol uses a catalytic amount of a nickel complex generated in situ from Ni(cod) 2 and dppf as diphosphine. The use of DMSO as the reaction solvent is crucial to control the regioselectivity of the reaction with the exclusive formation of the N ‐allyl product among up to three possible products.

Domaines

Chimie
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Dates et versions

hal-04396117 , version 1 (15-01-2024)

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Citer

Bouchaib Mouhsine, Abdallah Karim, Clément Dumont, Anthony Saint Pol, Isabelle Suisse, et al.. The Selective Nickel‐Catalyzed N ‐Allylation of C3‐Unprotected Indoles under Mild and Clean Conditions. European Journal of Organic Chemistry, 2022, 2022 (26), ⟨10.1002/ejoc.202200042⟩. ⟨hal-04396117⟩
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