The Selective Nickel‐Catalyzed N ‐Allylation of C3‐Unprotected Indoles under Mild and Clean Conditions
Résumé
Abstract A simple salt free and selective N ‐allylation of indoles with allylic alcohols has been developed. The protocol uses a catalytic amount of a nickel complex generated in situ from Ni(cod) 2 and dppf as diphosphine. The use of DMSO as the reaction solvent is crucial to control the regioselectivity of the reaction with the exclusive formation of the N ‐allyl product among up to three possible products.