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Journal Articles European Biophysics Journal Year : 2008

Non-Gaussian curvature distribution of actin-propelled biomimetic colloid trajectories

Abstract

We analyze the motion of colloids propelled by a comet-like tail of polymerizing actin filaments. The curvature of the particle trajectories deviates strongly from a Gaussian distribution, implying that the underlying microscopic processes are fluctuating in a non-independent manner. Trajectories for beads of different size all showed the same non-Gaussian behavior, while the mean curvature decreased weakly with size. A stochastic simulation that includes nucleation, force-dependent dissociation, growth, and capping of filaments, shows that the non-Gaussian curvature distribution can be explained by a positive feedback mechanism in which attached chains under higher tension are more likely to snap.
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hal-04393817 , version 1 (15-01-2024)

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Stephan Schmidt, Jasper van der Gucht, P. Maarten Biesheuvel, Richard Weinkamer, Emmanuèle Helfer, et al.. Non-Gaussian curvature distribution of actin-propelled biomimetic colloid trajectories. European Biophysics Journal, 2008, 37, pp.1361-1366. ⟨10.1007/s00249-008-0340-x⟩. ⟨hal-04393817⟩
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