The Nitric Oxide Releasing Agent Sodium Nitroprusside Modulates Cocaine‐Induced Immediate Early Gene Expression in Rat Brain - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Annals of the New York Academy of Sciences Année : 2006

The Nitric Oxide Releasing Agent Sodium Nitroprusside Modulates Cocaine‐Induced Immediate Early Gene Expression in Rat Brain

Résumé

A bstract : The nitric oxide (NO)/cGMP pathway triggers key events in synaptic phenomena involved in learning and memory. Using in situ hybridization, the present report demonstrates that NO released by sodium nitroprusside regulates egr‐1, c‐fos , and junB immediate early gene expression in rat forebrain. These genes, which are rapidly and transiently induced in response to diverse extracellular stimulation, coordinate alterations in gene expression underlying neuronal plasticity. Intracerebroventricular injection of sodium nitroprusside induced immediate early gene expression, which was highest in the nucleus accumbens. On the other hand, sodium nitroprusside abolished the cocaine‐induced early gene expression in the dopaminergic projection fields nucleus accumbens, caudate‐putamen, and frontal cortex. Further studies are warranted to explore the potential of the NO/cGMP/cGMP‐dependent protein kinase pathway to modify cocaine‐related behavioral effects.

Dates et versions

hal-04393515 , version 1 (14-01-2024)

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Citer

Nathalie Thiriet, Dominique Aunis, Jean Zwiller. The Nitric Oxide Releasing Agent Sodium Nitroprusside Modulates Cocaine‐Induced Immediate Early Gene Expression in Rat Brain. Annals of the New York Academy of Sciences, 2006, 965 (1), pp.47-54. ⟨10.1111/j.1749-6632.2002.tb04150.x⟩. ⟨hal-04393515⟩
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