Synthesis and Direct Ink Writing of doped β-tricalcium phosphate bioceramics for bone repair applications - Archive ouverte HAL Accéder directement au contenu
Communication Dans Un Congrès Année : 2023

Synthesis and Direct Ink Writing of doped β-tricalcium phosphate bioceramics for bone repair applications

Nicolas Somers
Florian Jean
Nicolas Preux
  • Fonction : Auteur
Cathy Delmotte
  • Fonction : Auteur
Laurent Boilet
Fabrice Petit
  • Fonction : Auteur
Anne Leriche

Résumé

Introduction β-tricalcium phosphate (β-TCP, β-Ca3(PO4)2) is one of the most attractive biomaterials for bone regeneration and β-TCP macroporous scaffolds are highly promising for bone tissue engineering. Direct Ink Writing (DIW), an additive manufacturing process based on the extrusion of a concentrated ceramic slurry, is particularly adapted to resolve the main drawbacks associated with conventional shaping of ceramic scaffolds. Methods In this work, undoped and co-doped β-TCP powders were synthetized by aqueous precipitation and used to print macroporous scaffolds by DIW. The doped compositions were produced combining magnesium, strontium, silver and copper cations: Mg-Sr (2.0–2.0 mol%) and Mg-Sr-Ag-Cu (2.0–2.0–0.1–0.1 mol%). DIW slurries were optimized with undoped and co-doped β-TCP with the use of a dispersant and a carboxymethylcellulose and polyethyleneimine mixture to obtain aqueous slurries filled with 42 vol% of powder. Undoped and co-doped β-TCP macroporous scaffolds were successfully printed by DIW and characterized. Results Doped β-TCP powders have been proved to exhibit higher thermal stability and densification compared to undoped β-TCP. The β-TCP slurries exhibited a shear-thinning and thixotropic behaviour suitable for the DIW process. The whole processing chain including printing, osmotic drying and sintering was optimized. Characterizations of the printed parts after sintering showed a reduction of macropores and microcracks using co-doped β-TCP powders as well as improved compressive strengths and densities compared to undoped β-TCP. Conclusion Improved compressive strength and densities were observed for co-doped β-TCP scaffolds with a significant enhancement by comparison with literature data. These results are encouraging for the development of on-demand customized bone substitutes applied to load-bearing areas. It was demonstrated that the developed process was successively applied to produce complex shapes, opening new possibilities for the fabrication of synthetic bone substitutes or other applications.

Domaines

Matériaux
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Dates et versions

hal-04393194 , version 1 (14-01-2024)

Identifiants

  • HAL Id : hal-04393194 , version 1

Citer

Marie Lasgorceix, Nicolas Somers, Florian Jean, Nicolas Preux, Cathy Delmotte, et al.. Synthesis and Direct Ink Writing of doped β-tricalcium phosphate bioceramics for bone repair applications. Bioceramics 33, Oct 2023, Solothurn, Switzerland. ⟨hal-04393194⟩
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