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Poster De Conférence Année : 2023

Antimicrobial integrated methodologies for orthopaedic applications

Résumé

OBJECTIVES OF THE CONSORTIUM AIMed is an Innovative Training Network (ITN) of 12 beneficiaries, 7 partners and 15 early stage researchers (ESR) aiming to develop new biomaterials that will eventually result in fewer orthopaedic infections, faster recovery of patients, and greatly reduced post-operative healthcare costs. Indeed, nosocomial infections are a major issue for biomaterials incorporation in the human body and reducing them is critical. AIMed will develop several complementary approaches to :  Create new antimicrobial metallic, polymeric and ceramic surfaces by the use of chemical and physical surface modification to allow functionalisation of surfaces with antimicrobial peptides, doping with metal ion antibacterial agents and patterning of surfaces at micro and nanoscale to study physical mechanisms underlying antimicrobial action.  Create novel antimicrobial peptides mimicking the antimicrobial core of human alphaand beta- defensins to realise antibacterial structures and use of molecular biology techniques to identify the best possible sequences. RESULTS AND MAIN FINDINGS of CERAMATHS in AIMed CERAMATHS is involved in several parts of the project :  Synthesis of AMPs by molecular biology routes based on peptide design from UoB and their comparison to chemical synyhesis process. Materials functionalisation is processed via several techniques as biomimetic synthesis of ceramic powders (Ruđer Bošković Institute, Croatia), polymer co-production (Universita degli studi di Trieste, Italy) and peptide-surface interactions and release will be studied (Université Paul Sabatier Toulouse III).  Biological characterization of new materials: antibacterial effects, cytotoxicity, cell viability.Physical and biological characterisation of laser patterned substrates produced by Institute of Electronics- Bulgarian Academy of Science, Bulgaria)
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Dates et versions

hal-04392043 , version 1 (13-01-2024)

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  • HAL Id : hal-04392043 , version 1

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Edwige Meurice, Cristina Cantallops-Vila, Marie Lasgorceix, Artemis Stamboulis, Anne Leriche. Antimicrobial integrated methodologies for orthopaedic applications. Workshop for Multi-Functional Materials, Jun 2023, Valenciennes, France. ⟨hal-04392043⟩
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