In the present paper, we consider large-scale differential Lyapunov matrix equations having a low rank constant term. We present two new approaches for the numerical resolution of such differential matrix equations. The first approach is based on the integral expression of the exact solution and an approximation method for the computation of the exponential of a matrix times a block of vectors. In the second approach, we first project the initial problem onto a block (or extended block) Krylov subspace and get a low-dimensional differential Lyapunov matrix equation. The latter differential matrix problem is then solved by the Backward Differentiation Formula method (BDF) and the obtained solution is used to build a low rank approximate solution of the original problem. The process is being repeated, increasing the dimension of the projection space until some prescribed accuracy is achieved. We give some new theoretical results and present numerical experiments.