Migrasomes are enigmatic organelles with a pomegranate‐like shape that form along the retraction fibres in migrating cells. They have been linked to several cellular functions including intercellular communication, by local transfer and at distance, and the disposal of damaged cellular materials, such as mitochondria. Yongbin Ma et al have uncovered that a unique type of lipid‐bilayer membrane vesicles is released from migrasomes, and called under the name migrasome‐derived nanoparticles (MDNP). Their observations suggest that MDNP can be generated upon both rupture and budding of migrasomes, ultimately unloading their content in the microenvironment.