Prognostic and Predictive Value of LIV1 Expression in Early Breast Cancer and by Molecular Subtype - Archive ouverte HAL Access content directly
Journal Articles Pharmaceutics Year : 2023

Prognostic and Predictive Value of LIV1 Expression in Early Breast Cancer and by Molecular Subtype

Abstract

Background: LIV1 is a transmembrane protein that may become a new therapeutic target through the development of antibody–drug conjugates (ADCs). Few studies are available regarding the assessment of LIV1 expression in clinical breast cancer (BC) samples. Methods: We analyzed LIV1 mRNA expression in 8982 primary BC. We searched for correlations between LIV1 expression and clinicopathological data, including disease-free survival (DFS), overall survival (OS), pathological complete response to chemotherapy (pCR), and potential vulnerability and actionability to anti-cancer drugs used or under development in BC. Analyses were performed in the whole population and each molecular subtype separately. Results: LIV1 expression was associated with good-prognosis features and with longer DFS and OS in multivariate analysis. However, patients with high LIV1 expression displayed a lower pCR rate than patients with low expression after anthracycline-based neoadjuvant chemotherapy, including in multivariate analysis adjusted on grade and molecular subtypes. LIV1-high tumors were associated with higher probabilities of sensitivity to hormone therapy and CDK4/6 inhibitors and lower probabilities of sensitivity to immune-checkpoint inhibitors and PARP inhibitors. These observations were different according to the molecular subtypes when analyzed separately. Conclusions: These results may provide novel insights into the clinical development and use of LIV1-targeted ADCs by identifying prognostic and predictive value of LIV1 expression in each molecular subtype and associated vulnerability to other systemic therapies.
Fichier principal
Vignette du fichier
pharmaceutics-15-00938.pdf (1.57 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-04390874 , version 1 (12-02-2024)

Identifiers

Cite

Alexandre de Nonneville, Pascal Finetti, Laurys Boudin, Emilie Denicolaï, Daniel Birnbaum, et al.. Prognostic and Predictive Value of LIV1 Expression in Early Breast Cancer and by Molecular Subtype. Pharmaceutics, 2023, 15 (3), pp.938. ⟨10.3390/pharmaceutics15030938⟩. ⟨hal-04390874⟩

Collections

CNRS UNIV-AMU CRCM
3 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More