Three-Year Overall Survival of Patients With Advanced Non–Small-Cell Lung Cancers With ≥50% PD-L1 Expression Treated With First-Line Pembrolizumab Monotherapy in a Real-World Setting (ESCKEYP GFPC Study) - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Immunotherapy Année : 2024

Three-Year Overall Survival of Patients With Advanced Non–Small-Cell Lung Cancers With ≥50% PD-L1 Expression Treated With First-Line Pembrolizumab Monotherapy in a Real-World Setting (ESCKEYP GFPC Study)

Chantal Decroisette
  • Fonction : Auteur
Hubert Curcio
  • Fonction : Auteur
Maurice Pérol
  • Fonction : Auteur
Charles Ricordel
  • Fonction : Auteur
Jean-Bernard Auliac
  • Fonction : Auteur
Lionel Falchero
  • Fonction : Auteur
Remi Veillon
  • Fonction : Auteur
Sabine Vieillot
  • Fonction : Auteur
Florian Guisier
  • Fonction : Auteur
Marie Marcq
  • Fonction : Auteur
Grégoire Justeau
  • Fonction : Auteur
Laurence Bigay-Game
  • Fonction : Auteur
Marie Bernardi
  • Fonction : Auteur
Hélène Doubre
  • Fonction : Auteur
Julian Pinsolle
  • Fonction : Auteur
Karim Amrane
  • Fonction : Auteur
Christos Chouaïd
  • Fonction : Auteur
Renaud Descourt
  • Fonction : Auteur

Résumé

Outside clinical trials, few data are available on the effect of long-term first-line pembrolizumab in patients with advanced non–small-cell lung cancers with ≥50% of tumor cells expressing programmed cell death ligand 1 (PD-L1). This French, multicenter study included consecutive advanced patients with non–small-cell lung cancer given first-line pembrolizumab alone between May 2017 (authorization date for this indication) and November 2019 (authorization date for pembrolizumab–chemotherapy combination). Information was collected from patients’ medical files, with a local evaluation of the response and progression-free survival (PFS). Overall survival (OS) was calculated from pembrolizumab onset using the Kaplan-Meier method. The analysis concerned 845 patients, managed in 33 centers: median age: 65 (range: 59–72) years, 67.8% men, 78.1% Eastern Cooperative Oncology Group performance status 0/1, 38.9%/51.5%/6.6% active, ex or never-smokers, respectively, 10.9%/16.8% taking or recently took corticosteroids/antibiotics, 69.6% nonsquamous histology, 48.9% ≥75% PD-L1–positive, and 20.8% had brain metastases at diagnosis. After a median (95% CI) follow-up of 45 (44.1–45.9) months, respective median (95% CI) PFS and OS lasted 8.2 (6.9–9.2) and 22 (8.5–25.9) months; 3-year PFS and OS rates were 25.4% and 39.4%, respectively. Multivariate analysis retained never-smoker status, adenocarcinoma histology, Eastern Cooperative Oncology Group performance status ≥2, and neutrophil/lymphocyte ratio >4 as being significantly associated with shorter survival, but not brain metastases at diagnosis or <75% PD-L1 tumor-cell expression. These long-term results of pembrolizumab efficacy based on a nationwide “real-world” cohort reproduced those obtained in clinical trials.

Domaines

Cancer
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Dates et versions

hal-04390230 , version 1 (12-01-2024)

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Citer

Chantal Decroisette, Laurent Greillier, Hubert Curcio, Maurice Pérol, Charles Ricordel, et al.. Three-Year Overall Survival of Patients With Advanced Non–Small-Cell Lung Cancers With ≥50% PD-L1 Expression Treated With First-Line Pembrolizumab Monotherapy in a Real-World Setting (ESCKEYP GFPC Study). Journal of Immunotherapy, 2024, 47 (1), pp.16-20. ⟨10.1097/CJI.0000000000000490⟩. ⟨hal-04390230⟩
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