Distribution and transport are considered to be key factors determining the quality of service and logistics costs, as they provide the connection between the different levels of the Supply Chain (SC). This study proposes a guideline to help industrial manufacturing companies manage their logistics distribution systems in an efficient and optimized way. The aim of the paper is to present a new approach to modeling and optimizing the connected distribution logistics process and flow in order to clarify its understanding and optimize its performance. This modeling of the downstream SC is based on a SC operations reference model (SCOR). We will be looking at the modeling and optimization of SC distribution logistics flows, followed by the integration of 4.0 technologies. This combination refers to efficient management of the movement of products and information throughout the distribution chain, based on advanced communication and connectivity technologies. Thanks to the technologies made available by Industry 4.0, it has become possible to optimize distribution in real time while proactively anticipating potential disruptions that may occur in the environment.