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Article Dans Une Revue Bioorganic Chemistry Année : 2021

Influence of core extension and side chain nature in targeting G-quadruplex structures with perylene monoimide derivatives

Résumé

Abstract Recent studies indicate that i‐DNA, a four‐stranded cytosine‐rich DNA also known as the i‐motif, is actually formed in vivo; however, a systematic study on sequence effects on stability has been missing. Herein, an unprecedented number of different sequences (271) bearing four runs of 3–6 cytosines with different spacer lengths has been tested. While i‐DNA stability is nearly independent on total spacer length, the central spacer plays a special role on stability. Stability also depends on the length of the C‐tracts at both acidic and neutral pHs. This study provides a global picture on i‐DNA stability thanks to the large size of the introduced data set; it reveals unexpected features and allows to conclude that determinants of i‐DNA stability do not mirror those of G‐quadruplexes. Our results illustrate the structural roles of loops and C‐tracts on i‐DNA stability, confirm its formation in cells, and allow establishing rules to predict its stability.

Dates et versions

hal-04387842 , version 1 (11-01-2024)

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Natalia Busto, José García-Calvo, José Vicente Cuevas, Antonio Herrera, Jean-Louis Mergny, et al.. Influence of core extension and side chain nature in targeting G-quadruplex structures with perylene monoimide derivatives. Bioorganic Chemistry, 2021, 108 (18), pp.104660. ⟨10.1016/j.bioorg.2021.104660⟩. ⟨hal-04387842⟩
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