Efficacy of careHPV ™ human papillomavirus screening versus conventional cytology tests for the detection of precancerous and cancerous cervical lesions among women living with HIV‐1 in Lao People's Democratic Republic - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cancer Medicine Année : 2022

Efficacy of careHPV ™ human papillomavirus screening versus conventional cytology tests for the detection of precancerous and cancerous cervical lesions among women living with HIV‐1 in Lao People's Democratic Republic

Phimpha Paboriboune
  • Fonction : Auteur
Keokedthong Phongsavan
  • Fonction : Auteur
Phetsamone Arounlangsy
  • Fonction : Auteur
Bruno Flaissier
  • Fonction : Auteur
Oukham Aphayarath
  • Fonction : Auteur
Prasit Phimmasone
  • Fonction : Auteur
Ketmala Banchongphanith
  • Fonction : Auteur
Mixi Xayaovong
  • Fonction : Auteur
Gonzague Jourdain
  • Fonction : Auteur
Anne‐marie Schott
  • Fonction : Auteur
Mitra Saadatian-Elahi
Laurent Magaud
  • Fonction : Auteur
Nicole Ngo-Giang-Huong
Isabelle Heard
  • Fonction : Auteur
Muriel Rabilloud
  • Fonction : Auteur
Valentina Sanchez Picot
  • Fonction : Auteur
Christophe Longuet
  • Fonction : Auteur

Résumé

Abstract Background In the Lao People's Democratic Republic (Lao PDR), cervical cancer is the third leading cause of women cancer. Aims The objective of this cross‐sectional study was to compare the efficacy of careHPV ™ test versus conventional Pap smear or Siriraj liquid‐based cytology in the detection of cervical cancer in women living with human immunodeficiency virus type 1 (HIV‐1). Materials & Methods Overall, 631 women consented to participate. Four cervical specimens were taken for the purpose of conventional Pap smear, Siriraj liquid‐based cytology, careHPV ™ test, and HPV‐16 genotyping. The exact McNemar test was used to compare the efficacy and diagnostic performance of the tests. Results Of the 631 women with follow‐up, 331 were human papillomavirus (HPV) negative. High‐grade squamous intraepithelial lesions were found in 37 women, biopsy‐proven high‐grade cervical intraepithelial neoplasia in 50 women, and invasive carcinoma in seven women. The proportion of women with high‐grade cervical lesion or carcinoma detected after abnormal careHPV ™ test was higher (6.02%; 95% confidence interval [CI]: 4.4–8.1) than that detected by conventional Pap smear (4.59%; 95% CI: 3.2–6.5). careHPV ™ and HPV‐16 genotyping had, respectively, the highest sensitivity (80.8%; 95% CI: 67.4–89.5) and specificity (92.2%; 95% CI: 89.8–94.2). HPV‐16 was the most frequently detected genotype. Conclusions careHPV ™ test represents a screening option in Lao PDR, particularly in women living with HIV‐1 because of higher prevalence of chronic HPV in this population.

Dates et versions

hal-04384324 , version 1 (10-01-2024)

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Phimpha Paboriboune, Keokedthong Phongsavan, Phetsamone Arounlangsy, Bruno Flaissier, Oukham Aphayarath, et al.. Efficacy of careHPV ™ human papillomavirus screening versus conventional cytology tests for the detection of precancerous and cancerous cervical lesions among women living with HIV‐1 in Lao People's Democratic Republic. Cancer Medicine, 2022, 11 (9), pp.1984-1994. ⟨10.1002/cam4.4502⟩. ⟨hal-04384324⟩
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