Outcomes of pregnancies with preterm premature rupture of membranes occurring before 24 weeks of gestation: An 11‐year observational study - Archive ouverte HAL Access content directly
Journal Articles International Journal of Gynecology and Obstetrics Year : 2023

Outcomes of pregnancies with preterm premature rupture of membranes occurring before 24 weeks of gestation: An 11‐year observational study

Abstract

Abstract Objective This study describes the fetal and neonatal outcomes and their predictive factors in pregnancies with preterm premature rupture of membranes (PPROM) before 24 weeks of gestation. Methods A retrospective study was conducted using the patient database of a tertiary university hospital in Lyon, France. All of the medical data of women diagnosed with PPROM before 24 weeks of gestation from 2008 to 2018 were extracted. R software was used for descriptive and analytical statistics. Results The study included 78 women. Mean gestational age (GA) at PPROM was 19.6 weeks (13.1 to 23.9 weeks). Fifteen (19.2%) pregnancies were terminated, 37 (47.4%) resulted in intrauterine fetal death (IUFD), and 26 (33.3%) children were born alive at an average of 26.9 weeks of gestation. Fourteen children survived and 12 died after birth; 50% of survivors had pulmonary hypoplasia. Within 7 days after PPROM, 46% of IUFD occurred and 36% of pregnancies ended. PPROM before 20 weeks of gestation and chorioamnionitis are statistically associated with IUFD, whereas a latency period of more than 2 weeks is statistically related to live birth. Conclusion PPROM before 24 weeks of gestation is associated with a high rate of IUFD, preterm birth, and postpartum mortality.
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Dates and versions

hal-04382548 , version 1 (09-01-2024)

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Helene Gauthier-Moulinier, Daouda Ndour, Muriel Rabilloud, Kim‐an Nguyen. Outcomes of pregnancies with preterm premature rupture of membranes occurring before 24 weeks of gestation: An 11‐year observational study. International Journal of Gynecology and Obstetrics, 2023, 162 (2), pp.590-595. ⟨10.1002/ijgo.14700⟩. ⟨hal-04382548⟩
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