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Chapitre D'ouvrage Année : 2021

Aptamers for Molecular Imaging

Résumé

Nucleic acid aptamers have been selected against a wide variety of targets and are increasingly used in biotechnological applications where they are often compared to “chemical antibodies” Because of their high specificity and affinity, aptamers are promising tools for molecular imaging. They have been evaluated over the last 20 years in almost every imaging modality, including single photon emission computed tomography, positron emission tomography, fluorescence imaging, magnetic resonance imaging, X-ray computed tomography, and ultrasound imaging. This chapter explains the different processes that are used to develop a molecular imaging probe with an aptamer, presenting its selection, optimization, labeling, and preclinical evaluation by molecular imaging. It also discusses potential pitfalls that may be encountered and important controls to be applied.

Dates et versions

hal-04382478 , version 1 (09-01-2024)

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Copyright (Tous droits réservés)

Identifiants

Citer

Frédéric Ducongé. Aptamers for Molecular Imaging. Brian D. Ross and Sanjiv Sam Gambhir. Molecular Imaging - Second Edition, 1, Elsevier, pp.699-715, 2021, ⟨10.1016/B978-0-12-816386-3.00034-X⟩. ⟨hal-04382478⟩
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