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Pré-Publication, Document De Travail Année : 2023

Dissecting stochasticity in the temporal progression of translation: What exactly “can be otherwise”?

Marco Casali
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Alberto Vianelli
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Résumé

With a few exceptions, biological research dealing with stochasticity in molecular and cellular biology have focused on transcriptional processes (e.g., Elowitz et al 2002; Lipniacki et al 2006). Consequently, philosophical analyses have also centered on its role in transcription (e.g., Casali and Merlin 2020). Nonetheless, recent empirical evidence clearly shows that stochasticity is pervasive in translation too (e.g., Boersma et al 2019). Focusing on a noncanonical case of translation (i.e., start codon selection), this paper aims to disentangle two ways in which stochasticity can intervene in this intracellular process. Having provided a definition of what we mean by stochasticity, we first focus on the parameter of time. By introducing two temporal models, we show where and how stochasticity can make a difference in the timing of translation process. Second, we show how this difference can be biologically relevant for cell physiology. We conclude that, from an explanatory point of view, it is thus worth dissecting stochasticity when studying translation, gene expression and, more generally, biological processes at the molecular level.
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Dates et versions

hal-04382309 , version 1 (09-01-2024)

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  • HAL Id : hal-04382309 , version 1

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Francesca Merlin, Marco Casali, Alberto Vianelli. Dissecting stochasticity in the temporal progression of translation: What exactly “can be otherwise”?. 2023. ⟨hal-04382309⟩
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