Cohort profile: COBLAnCE: a French prospective cohort to study prognostic and predictive factors in bladder cancer and to generate real-world data on treatment patterns, resource use and quality of life - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue BMJ Open Année : 2023

Cohort profile: COBLAnCE: a French prospective cohort to study prognostic and predictive factors in bladder cancer and to generate real-world data on treatment patterns, resource use and quality of life

Thierry Lebret
  • Fonction : Auteur
Julia Bonastre
  • Fonction : Auteur
Aldéric Fraslin
Yann Neuzillet
  • Fonction : Auteur
Stéphane Droupy
  • Fonction : Auteur
Xavier Rebillard
  • Fonction : Auteur
Dimitri Vordos
  • Fonction : Auteur
Arnauld Villers
  • Fonction : Auteur
Marc Schneider
  • Fonction : Auteur
Patrick Coloby
  • Fonction : Auteur
Jean Lacoste
  • Fonction : Auteur
Arnaud Méjean
  • Fonction : Auteur
Jacques Lacoste
  • Fonction : Auteur
Jean-Luc Descotes
  • Fonction : Auteur
Pascal Eschwege
  • Fonction : Auteur
Guillaume Loison
  • Fonction : Auteur
Hélène Blanché
  • Fonction : Auteur
Odette Mariani
  • Fonction : Auteur
Bijan Ghaleh
  • Fonction : Auteur
Anthony Mangin
  • Fonction : Auteur
Nanor Sirab
  • Fonction : Auteur
Karine Groussard
  • Fonction : Auteur
François Radvanyi
  • Fonction : Auteur
Yves Allory
  • Fonction : Auteur

Résumé

Purpose Bladder cancer is a complex disease with a wide range of outcomes. Clinicopathological factors only partially explain the variability between patients in prognosis and treatment response. There is a need for large cohorts collecting extensive data and biological samples to: (1) investigate gene-environment interactions, pathological/molecular classification and biomarker discovery; and (2) describe treatment patterns, outcomes, resource use and quality of life in a real-world setting. Participants COBLAnCE ( CO hort to study BLA dder C anc E r) is a French national prospective cohort of patients with bladder cancer recruited between 2012 and 2018 and followed for 6 years. Data on patient and tumour characteristics, treatments, outcomes and biological samples are collected at enrolment and during the follow-up. Findings to date We describe the cohort at enrolment according to baseline surgery and tumour type. In total, 1800 patients were included: 1114 patients with non-muscle-invasive bladder cancer (NMIBC) and 76 patients with muscle-invasive bladder cancer (MIBC) had transurethral resection of a bladder tumour without cystectomy, and 610 patients with NMIBC or MIBC underwent cystectomy. Most patients had a solitary lesion (56.3%) without basement membrane invasion (71.7% of Ta and/or Tis). Half of the patients with cystectomy were stage ≤T2 and 60% had non-continent diversion. Surgery included local (n=298) or super-extended lymph node dissections (n=11) and prostate removal (n=492). Among women, 16.5% underwent cystectomy and 81.4% anterior pelvectomy. Future plans COBLAnCE will be used for long-term studies of bladder cancer with focus on clinicopathological factors and molecular markers. It will lead to a much-needed improvement in the understanding of the disease. The cohort provides valuable real-world data, enabling researchers to study various research questions, assess routine medical practices and guide medical decision-making.

Domaines

Cancer

Dates et versions

hal-04381735 , version 1 (09-01-2024)

Identifiants

Citer

Thierry Lebret, Julia Bonastre, Aldéric Fraslin, Yann Neuzillet, Stéphane Droupy, et al.. Cohort profile: COBLAnCE: a French prospective cohort to study prognostic and predictive factors in bladder cancer and to generate real-world data on treatment patterns, resource use and quality of life. BMJ Open, 2023, 13 (12), pp.e075942. ⟨10.1136/bmjopen-2023-075942⟩. ⟨hal-04381735⟩
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