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Article Dans Une Revue Neuromuscular Disorders Année : 2018

High urinary ferritin reflects myoglobin iron evacuation in DMD patients

Jérémy Rouillon
  • Fonction : Auteur
Thibaud Lefebvre
Jérôme Denard
Vincent Puy
  • Fonction : Auteur
Raed Daher
  • Fonction : Auteur
Jérôme Ausseil
  • Fonction : Auteur
Aleksandar Zocevic
  • Fonction : Auteur
Paul Fogel
  • Fonction : Auteur
Katell Peoc'H
Brenda Wong
Laurent Servais
  • Fonction : Auteur
Thomas Voit
  • Fonction : Auteur
Herve Puy
  • Fonction : Auteur
Zoubida Karim
  • Fonction : Auteur
Fedor Svinartchouk

Résumé

Duchenne muscular dystrophy (DMD) is an X-linked disease caused by mutations in the dystrophin gene leading to the absence of the normal dystrophin protein. The efforts of many laboratories brought new treatments of DMD to the reality, but ongoing and forthcoming clinical trials suffer from absence of valuable biomarkers permitting to follow the outcome of the treatment day by day and to adjust the treatment if needed. In the present study the levels of 128 urinary proteins including growth factors, cytokines and chemokines were compared in urine of DMD patients and age related control subjects by antibody array approach. Surprisingly, statistically significant difference was observed only for urinary ferritin whose level was 50 times higher in young DMD patients. To explain the observed high urinary ferritin content we analysed the levels of iron, iron containing proteins and proteins involved in regulation of iron metabolism in serum and urine of DMD patients and their age-matched healthy controls. Obtained data strongly suggest that elevated level of urinary ferritin is functionally linked to the renal management of myoglobin iron derived from leaky muscles of DMD patients. This first observation of the high level of ferritin in urine of DMD patients permits to consider this protein as a new urinary biomarker in muscular dystrophies and sheds light on the mechanisms of iron metabolism and kidney functioning in DMD.
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Dates et versions

hal-04380471 , version 1 (11-01-2024)

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Jérémy Rouillon, Thibaud Lefebvre, Jérôme Denard, Vincent Puy, Raed Daher, et al.. High urinary ferritin reflects myoglobin iron evacuation in DMD patients. Neuromuscular Disorders, 2018, 28 (7), pp.564-571. ⟨10.1016/j.nmd.2018.03.008⟩. ⟨hal-04380471⟩
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