Seismic faults release the stress accumulated during tectonic movement through rapid ruptures or slow slip events. The slow slip events play a crucial role in the seismic cycle as they impact the occurrence of earthquakes. However, the mechanisms by which a slow-slip region affects the dynamics of frictionally locked regions remain elusive. Here, building on model laboratory experiments, we establish that a slow-slip region acts as a nucleation center for seismic rupture, thereby enhancing earthquakes' frequency. We emulate slow-slip regions by introducing a granular material patch along part of a laboratory fault. By measuring the response of the fault to shear, we show that the role of the heterogeneity is to serve as a seed crack for rapid ruptures, reducing fault shear resistance. Additionally, by varying the external normal load, we show that the slow-slip region extends beyond the heterogeneity, demonstrating that fault composition is not the only requirement for slow-slip, but that load also plays a role. Our findings demonstrate that fracture concepts single out the very origin of earthquake nucleation and slip dynamics in seismic faults. The interplay between slowly-slipping and locked regions that we identify provides a promising avenue to monitor fault propagation and mitigate seismic hazards.