Vesicular Trafficking, a Mechanism Controlled by Cascade Activation of Rab Proteins: Focus on Rab27
Résumé
Vesicle trafficking is governed by the careful regulation of RabGTPase activation/inactivation, which promotes vesicle formation from a donor membrane, motility, docking/tethering and fusion with a recipient membrane. This review highlights the main Rab proteins involved in these processes under physiological conditions, and focuses on the pathophysiological role of the two Rab27 isoforms. This review presents the interest in studying Rab proteins and their effectors in the regulation of vesicular trafficking, and opens the interest of considering them in pathological conditions as outcomes for targeted therapeutical approaches.
Domaines
Sciences du Vivant [q-bio]
Origine : Publication financée par une institution
Licence : CC BY - Paternité
Licence : CC BY - Paternité