Modelling Keloids Dynamics: A Brief Review and New Mathematical Perspectives - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Bulletin of Mathematical Biology Année : 2023

Modelling Keloids Dynamics: A Brief Review and New Mathematical Perspectives

G. Rolin
  • Fonction : Auteur
O. Adebayo
  • Fonction : Auteur
S. Urcun
  • Fonction : Auteur
F. Chouly
  • Fonction : Auteur
S. Bordas
  • Fonction : Auteur

Résumé

Keloids are fibroproliferative disorders described by excessive growth of fibrotic tissue, which also invades adjacent areas (beyond the original wound borders). Since these disorders are specific to humans (no other animal species naturally develop keloid-like tissue), experimental in vivo/in vitro research has not led to significant advances in this field. One possible approach could be to combine in vitro human models with calibrated in silico mathematical approaches (i.e., models and simulations) to generate new testable biological hypotheses related to biological mechanisms and improved treatments. Because these combined approaches do not really exist for keloid disorders, in this brief review we start by summarising the biology of these disorders, then present various 1 types of mathematical and computational approaches used for related disorders (i.e., wound healing and solid tumours), followed by a discussion of the very few mathematical and computational models published so far to study various inflammatory and mechanical aspects of keloids. We conclude this review by discussing some open problems and mathematical opportunities offered in the context of keloid disorders by such combined in vitro/in silico approaches, and the need for multidisciplinary research to enable clinical progress.
Fichier principal
Vignette du fichier
BMBtemplate_Keloids_article_Revised-Unmarked.pdf (1.22 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Licence : CC BY - Paternité

Dates et versions

hal-04357185 , version 1 (21-12-2023)

Identifiants

Citer

Raluca Eftimie, G. Rolin, O. Adebayo, S. Urcun, F. Chouly, et al.. Modelling Keloids Dynamics: A Brief Review and New Mathematical Perspectives. Bulletin of Mathematical Biology, 2023, 85 (12), pp.117. ⟨10.1007/s11538-023-01222-8⟩. ⟨hal-04357185⟩
12 Consultations
25 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More