Chloroquine Inhibits the Release of Inflammatory Cytokines by Human Lung Explants - Archive ouverte HAL
Article Dans Une Revue Clinical Infectious Diseases Année : 2020

Chloroquine Inhibits the Release of Inflammatory Cytokines by Human Lung Explants

Résumé

Abstract On human lung parenchymal explants, chloroquine concentration clinically achievable in the lung (100 µM) inhibited the lipopolysaccharide-induced release of TNF-ɑ (by 76%), IL-6 (by 68%), CCL2 (by 72%), and CCL3 (by 67%). Besides its antiviral activity, chloroquine might also mitigate the cytokine storm associated with severe pneumonia caused by coronaviruses.

Dates et versions

hal-04357138 , version 1 (20-12-2023)

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Citer

Stanislas Grassin-Delyle, Hélène Salvator, Marion Brollo, Emilie Catherinot, Édouard Sage, et al.. Chloroquine Inhibits the Release of Inflammatory Cytokines by Human Lung Explants. Clinical Infectious Diseases, 2020, 71 (16), pp.2265-2268. ⟨10.1093/cid/ciaa546⟩. ⟨hal-04357138⟩
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