Influence of EE2 exposure, age and sex on telomere length in European long-snouted seahorse (Hippocampus guttulatus) - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue General and Comparative Endocrinology Année : 2024

Influence of EE2 exposure, age and sex on telomere length in European long-snouted seahorse (Hippocampus guttulatus)

Résumé

After a Telomere Lengthening in juvenile stage, a progressive telomere shortening occurs with age despite higher telomerase level. Telomere Length (TL) may also reflect past physiological state such as a chronic chemical stress. Several studies have revealed a correlation between TL, ageing and/or sex in vertebrates, including teleosts; however, the patterns of telomere dynamics with telomerase mRNA expression, sex, lifespan or chemical stress in teleosts are unclear. The first aim of this study is to verify if telomere length is age and sex-dependent. The second aim is to consider if TL is a useful indicator of stress response in European long-snouted seahorse, Hippocampus guttulatus, an ectothermic and non-model system. We showed that after telomere lengthening during the juvenile stage, a telomeric attrition became significant in sexually mature individuals (p = 0.042). TL decreased in older seahorses despite the presence of somatic telomerase mRNA expression at all life stages studied. There was no difference in TL between males and females, but telomerase mRNA expression was consistently higher in females than males. Exposure to EE2 had no effect on TL in young seahorses, but was correlated with a significant increase in telomerase mRNA expression and various physiological disruptions. Here, a growth retardation of −10 % for body length (p = 0.016) and approximately −45 % for mass (p = 0.001) compared to healthy juvenile seahorses was observed. Our data suggest that telomere dynamics alone should not be used as a marker of EE2 exposure in juvenile seahorses.
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Dates et versions

hal-04349100 , version 1 (21-02-2024)

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Nathalie Prévot d'Alvise, Eliette Ascensio, Simone Richard. Influence of EE2 exposure, age and sex on telomere length in European long-snouted seahorse (Hippocampus guttulatus). General and Comparative Endocrinology, 2024, 346 (15 January 2024), pp.114419. ⟨10.1016/j.ygcen.2023.114419⟩. ⟨hal-04349100⟩
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