Impact of ex vivo lung perfusion on brain-dead donor lung utilization: The French experience
Naïssa Abdoul
(1)
,
Camille Legeai
(1)
,
Christelle Cantrelle
(1)
,
Olaf Mercier
(2)
,
Anne Olland
(3, 4)
,
Pierre Mordant
(5)
,
Pascal Alexandre Thomas
(6, 7)
,
Jacques Jougon
(8)
,
Adrien Tissot
(9, 10, 11, 12, 13)
,
Jean-Michel Maury
(14)
,
Édouard Sage
(15, 16, 17)
,
Richard Dorent
(18, 1)
1
Agence de la biomédecine [Saint-Denis la Plaine]
2 Hôpital Marie-Lannelongue
3 NanoRegMed - Nanomédecine Régénérative
4 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
5 AP-HP - Hôpital Bichat - Claude Bernard [Paris]
6 CRCM - Centre de Recherche en Cancérologie de Marseille
7 Service de chirurgie thoracique [Hôpital Nord - APHM]
8 Hôpital Haut-Lévêque [CHU Bordeaux]
9 ITX-lab - ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291
10 Hôpital Guillaume-et-René-Laennec [Saint-Herblain]
11 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
12 U1064 Inserm - CR2TI - Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology
13 Team 4 - U1064 Inserm - CR2TI - Team 4 : Deciphering organ immune regulation in inflammation and transplantation (DORI-t)
14 IVPC - Infections Virales et Pathologie Comparée - UMR 754
15 VIM (UR 0892) - Virologie et Immunologie Moléculaires
16 Hôpital Foch [Suresnes]
17 CT2P - Hôpital Foch - Chirurgie thoracique et transplantation pulmonaire [Suresnes]
18 CHU Tenon [AP-HP]
2 Hôpital Marie-Lannelongue
3 NanoRegMed - Nanomédecine Régénérative
4 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
5 AP-HP - Hôpital Bichat - Claude Bernard [Paris]
6 CRCM - Centre de Recherche en Cancérologie de Marseille
7 Service de chirurgie thoracique [Hôpital Nord - APHM]
8 Hôpital Haut-Lévêque [CHU Bordeaux]
9 ITX-lab - ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291
10 Hôpital Guillaume-et-René-Laennec [Saint-Herblain]
11 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
12 U1064 Inserm - CR2TI - Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology
13 Team 4 - U1064 Inserm - CR2TI - Team 4 : Deciphering organ immune regulation in inflammation and transplantation (DORI-t)
14 IVPC - Infections Virales et Pathologie Comparée - UMR 754
15 VIM (UR 0892) - Virologie et Immunologie Moléculaires
16 Hôpital Foch [Suresnes]
17 CT2P - Hôpital Foch - Chirurgie thoracique et transplantation pulmonaire [Suresnes]
18 CHU Tenon [AP-HP]
Camille Legeai
- Fonction : Auteur
- PersonId : 1229050
- ORCID : 0000-0001-7752-1144
Olaf Mercier
- Fonction : Auteur
- PersonId : 739087
- IdHAL : olaf-mercier
- ORCID : 0000-0002-4760-6267
- IdRef : 076094820
Adrien Tissot
- Fonction : Auteur
Édouard Sage
- Fonction : Auteur
- PersonId : 1135354
- IdHAL : edouard-sage
Richard Dorent
- Fonction : Auteur
- PersonId : 762367
- ORCID : 0000-0002-6159-1372
Résumé
Abstract
Ex vivo lung perfusion (EVLP) is a valuable method for expanding the lung donor pool. Its indications currently differ across centers. This national retrospective cohort study aimed to describe the profile of donors with lungs transplanted after EVLP and determine the effectiveness of EVLP on lung utilization. We included brain-dead donors with at least one lung offered between 2012 and 2019 in France. Lungs transplanted without or after EVLP were compared with those that were rejected. Donor group phenotypes were determined with multiple correspondence analysis (MCA). The association between donor factors and lung transplantation was assessed with a multivariable multinomial logistic regression. MCA revealed that donors whose lungs were transplanted after EVLP had profiles similar to the donors whose lungs were declined and quite different from those of donors with lungs transplanted without EVLP. Donor predictors of graft nonuse included age ≥50 years, smoking history, PaO2 /FiO2 ratio ≤300 mmHg, abnormal chest imaging, and purulent secretions. EVLP increased utilization of lungs from donors with a smoking history, PaO2 /FiO2 ratio ≤300 mmHg, and abnormal chest imaging.
Mots clés
Format du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Impact of ex vivo lung perfusion on brain-dead donor lung utilization: The French experience
|
Résumé |
en
Abstract
Ex vivo lung perfusion (EVLP) is a valuable method for expanding the lung donor pool. Its indications currently differ across centers. This national retrospective cohort study aimed to describe the profile of donors with lungs transplanted after EVLP and determine the effectiveness of EVLP on lung utilization. We included brain-dead donors with at least one lung offered between 2012 and 2019 in France. Lungs transplanted without or after EVLP were compared with those that were rejected. Donor group phenotypes were determined with multiple correspondence analysis (MCA). The association between donor factors and lung transplantation was assessed with a multivariable multinomial logistic regression. MCA revealed that donors whose lungs were transplanted after EVLP had profiles similar to the donors whose lungs were declined and quite different from those of donors with lungs transplanted without EVLP. Donor predictors of graft nonuse included age ≥50 years, smoking history, PaO2 /FiO2 ratio ≤300 mmHg, abnormal chest imaging, and purulent secretions. EVLP increased utilization of lungs from donors with a smoking history, PaO2 /FiO2 ratio ≤300 mmHg, and abnormal chest imaging.
|
Auteur(s) |
Naïssa Abdoul
1
, Camille Legeai
1
, Christelle Cantrelle
1
, Olaf Mercier
2
, Anne Olland
3, 4
, Pierre Mordant
5
, Pascal Alexandre Thomas
6, 7
, Jacques Jougon
8
, Adrien Tissot
9, 10, 11, 12, 13
, Jean-Michel Maury
14
, Édouard Sage
15, 16, 17
, Richard Dorent
18, 1
1
Agence de la biomédecine [Saint-Denis la Plaine]
( 115378 )
- 1 avenue du stade de France
93212 SAINT-DENIS LA PLAINE Cedex
- France
2
Hôpital Marie-Lannelongue
( 322615 )
- 133 avenue de la Résistance,
92350 Le Plessis-Robinson
- France
3
NanoRegMed -
Nanomédecine Régénérative
( 543256 )
- 11 Rue Humann
Strasbourg - France
- France
4
CHU Strasbourg -
Centre Hospitalier Universitaire [Strasbourg]
( 300149 )
- France
5
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
( 300156 )
- 46 Rue Henri Huchard, 75018 Paris
- France
6
CRCM -
Centre de Recherche en Cancérologie de Marseille
( 179570 )
- 27 bd Leï Roure, BP 300059
13273 Marseille Cedex 09
- France
7
Service de chirurgie thoracique [Hôpital Nord - APHM]
( 567311 )
- France
8
Hôpital Haut-Lévêque [CHU Bordeaux]
( 301071 )
- France
9
ITX-lab -
ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291
( 1088523 )
- 8 quai Moncousu - BP 70721 - 44007 Nantes Cedex 1
- France
10
Hôpital Guillaume-et-René-Laennec [Saint-Herblain]
( 475892 )
- boulevard Jacques-Monod
Saint-Herblain
44093 Nantes Cedex 1
- France
11
CHU Nantes -
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
( 474972 )
- 1 Place Alexis-Ricordeau, 44000 Nantes
- France
12
U1064 Inserm - CR2TI -
Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology
( 1088530 )
- CHU Nantes - Hôtel Dieu - 30 Bd Jean Monnet 44093 Nantes Cedex 01.
- France
13
Team 4 - U1064 Inserm - CR2TI -
Team 4 : Deciphering organ immune regulation in inflammation and transplantation (DORI-t)
( 1114518 )
- CHU Nantes - Hôtel Dieu - 30 Bd Jean Monnet 44093 Nantes Cedex 01.
- France
14
IVPC -
Infections Virales et Pathologie Comparée - UMR 754
( 1002418 )
- 50 Avenue Tony Garnier
69366 Lyon Cedex 07
- France
15
VIM (UR 0892) -
Virologie et Immunologie Moléculaires
( 1002085 )
- INRAE Domaine de Vilvert F-78352 Jouy-en-Josas cedex
- France
16
Hôpital Foch [Suresnes]
( 410109 )
- 40 Rue Worth 92150 Suresnes
- France
17
CT2P - Hôpital Foch -
Chirurgie thoracique et transplantation pulmonaire [Suresnes]
( 1160301 )
- France
18
CHU Tenon [AP-HP]
( 328304 )
- 4 Rue de la Chine, 75020 Paris
- France
|
Audience |
Internationale
|
Comité de lecture |
Oui
|
Vulgarisation |
Non
|
Langue du document |
Anglais
|
Nom de la revue |
|
Date de publication |
2022-05
|
Volume |
22
|
Numéro |
5
|
Page/Identifiant |
1409-1417
|
Domaine(s) |
|
Mots-clés |
en
clinical research / practice, donors and donation: donation after brain death (DBD), donors and donation: donor evaluation, donors and donation: extended criteria, lung transplantation / pulmonology, organ perfusion and preservation, organ procurement and allocation, registry / registry analysis.
|
DOI | 10.1111/ajt.16953 |
Loading...