Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue European Journal of Nutrition Année : 2023

Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis

Fernanda Morales-Berstein
Ana Luiza Goncalves-Soares
  • Fonction : Auteur
Kiara Chu Mei Chang
Eszter Panna Vamos
  • Fonction : Auteur
Fernanda Fátima Rauber
Renata Bertazzi Levy
  • Fonction : Auteur
Diana Barbosa Cunha
  • Fonction : Auteur
Paula G. Jakszyn
Paolo Vineis
  • Fonction : Auteur
Giovanna Masala
Alberto Catalano
Emily Sonestedt
  • Fonction : Auteur
Yan Borné
  • Fonction : Auteur
Verena Andrea Katzke
  • Fonction : Auteur
Rashmita Bajracharya
  • Fonction : Auteur
Claudia Agnoli
Marcela M. Guevara
Alicia K. Heath
  • Fonction : Auteur
Elisabete Weiderpass
  • Fonction : Auteur
José Mª Huerta
Maria José Sánchez
Anne Tjønneland
  • Fonction : Auteur
C. Kyrø
Matthias Bernd Schulze
Guri Skeie
Marco Lukic
  • Fonction : Auteur
Tonje Bjørndal Braaten
  • Fonction : Auteur
Marc J.R. Gunter
  • Fonction : Auteur
Christopher J. Millett
  • Fonction : Auteur
A. T. Agudo
Paul J. Brennan
  • Fonction : Auteur
Maria Carolina Borges
Rebecca Claire Richmond
  • Fonction : Auteur
Tom G. Richardson
George Davey Smith
  • Fonction : Auteur
Caroline L. Relton
  • Fonction : Auteur
Inge Huybrechts
  • Fonction : Auteur

Résumé

Purpose: To investigate the role of adiposity in the associations between ultra-processed food (UPF) consumption and head and neck cancer (HNC) and oesophageal adenocarcinoma (OAC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Our study included 450,111 EPIC participants. We used Cox regressions to investigate the associations between the consumption of UPFs and HNC and OAC risk. A mediation analysis was performed to assess the role of body mass index (BMI) and waist-to-hip ratio (WHR) in these associations. In sensitivity analyses, we investigated accidental death as a negative control outcome. Results: During a mean follow-up of 14.13 ± 3.98 years, 910 and 215 participants developed HNC and OAC, respectively. A 10% g/d higher consumption of UPFs was associated with an increased risk of HNC (hazard ratio [HR] = 1.23, 95% confidence interval [CI] 1.14–1.34) and OAC (HR = 1.24, 95% CI 1.05–1.47). WHR mediated 5% (95% CI 3–10%) of the association between the consumption of UPFs and HNC risk, while BMI and WHR, respectively, mediated 13% (95% CI 6–53%) and 15% (95% CI 8–72%) of the association between the consumption of UPFs and OAC risk. UPF consumption was positively associated with accidental death in the negative control analysis. Conclusions: We reaffirmed that higher UPF consumption is associated with greater risk of HNC and OAC in EPIC. The proportion mediated via adiposity was small. Further research is required to investigate other mechanisms that may be at play (if there is indeed any causal effect of UPF consumption on these cancers).
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Dates et versions

hal-04342423 , version 1 (22-12-2023)

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Fernanda Morales-Berstein, Carine Biessy, Vivian Viallon, Ana Luiza Goncalves-Soares, Corinne Casagrande, et al.. Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis. European Journal of Nutrition, 2023, ⟨10.1007/s00394-023-03270-1⟩. ⟨hal-04342423⟩
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